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1994-10-25
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Document 2937
DOCN M94A2937
TI Pathogenicity of Entamoeba histolytica in Japanese male homosexual
population.
DT 9412
AU Takeuchi T; Kobayashi S; Okusawa E; Tachibana H; Takada S; Ohtomo H;
Department of Tropical Medicine and Parasitology, School of; Medicine,
Keio University, Tokyo, Japan.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):190 (abstract no. PB0189). Unique
Identifier : AIDSLINE ICA10/94369638
AB OBJECTIVE: In contrast to Western countries, there have been many cases
with invasive sexually transmitted amebiasis in Japan. This study was
attempted to delineate its epidemiological characteristics and clarify
the pathogenicity of the ameba isolates from Japanese homosexual
population. METHODS: The epidemiological aspects were assessed through
questionnaire to more than 1,500 hospitals in Japan. Zymodemes of the
ameba isolates were determined by Sargeaunt's method. Serologic
examination was done by the GDP, IFA and ELISA. Reactivity to monoclonal
antibodies was examined by IFA. Sera from homosexual men were collected
by the courtesy of Drs. M. Mizokami (Nagoya City Univ), S. Isomura
(Nagoya Univ) and J. Matsuda (Teikyo Univ). RESULTS: During 13 years
from 1980, we have had more than 150 Japanese male homosexuals with
invasive amebiasis. Seroepidemiological study showed that Japanese male
homosexual population was highly seropositive against amebic infection,
e.g., 4 to 20% by ELISA. All of the ameba isolates from the symptomatic
individuals were of pathogenic zymodemes. Of interest was zymodeme XIV
and XIX were frequently detected in addition of zymodeme 11. Moreover,
the ameba isolates readily reacted to MAb 4G6, which is pathogenic
isolate-specific, as tested by IFA. DISCUSSION AND CONCLUSION: These
findings suggest that in contrast to the epidemiology in Western
countries, pathogenic E. histolytica is spread among Japanese homosexual
men, which appears to be responsible for the occurrence of a large
number of cases with invasive sexually transmitted amebiasis.
DE Animal Antibodies, Protozoan/ANALYSIS AIDS-Related Opportunistic
Infections/IMMUNOLOGY/*PARASITOLOGY/ TRANSMISSION Entamoeba
histolytica/IMMUNOLOGY/*PATHOGENICITY
Entamoebiasis/IMMUNOLOGY/*PARASITOLOGY/TRANSMISSION *Homosexuality
Human Japan Male Sexually Transmitted
Diseases/IMMUNOLOGY/PARASITOLOGY/ TRANSMISSION Virulence MEETING
ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).